PhD-Kandidat*in (f/m/x) - Immune-non-immune Zell-Zell-Int...

PhD candidate (f/m/x) - Immune-non-immune cell-cell interactions in chronic obstructive pulmonary disease

102525

Full time
39 hrs/week

Munich

We are Helmholtz Munich. In a rapidly changing world, we discover breakthrough solutions for better health.

Our research is focused within the areas of metabolic health/diabetes, environmental health, molecular targets and therapies, cell programming and repair, bioengineering, and computational health. We particularly excel in the fields of basic research, bioengineering, artificial intelligence, and technological development.

Through this research, we build the foundations for medical innovation. Together with our partners, we seek to accelerate the transfer of our research, so that laboratory ideas can reach society and improve people’s quality of life at the fastest rate possible.

This is what drives us. Why not join us and make a difference?

Chronic obstructive pulmonary disease (COPD) is a progressive, debilitating respiratory condition characterized by persistent inflammation and irreversible tissue damage in the airways and lungs, driven by exposure to harmful agents like cigarette smoke and environmental pollutants. While the role of myeloid immune cells, such as monocytes/macrophages and neutrophils in sustaining chronic inflammation is well-established, the contributions of non-immune lung cells, such as epithelial, small capillaries, fibroblasts and smooth muscle cells are emerging as critical yet understudied factors. To investigate the dynamic crosstalk between immune and non-immune cells and their implications in lung injury and regeneration, the Kapellos lab is seeking to hire a talented PhD candidate (f/m/x) who will combine single-cell omics technologies with highly multiplexed imaging and in vitro functional assays.

Prof. Matthias Tschöp (Dr. Med., Dr. hc.), CEO of Helmholtz Munich:

"We believe that excellent research requires a range of different perspectives. Diverse teams reach better solutions and are more innovative in their research topics.

Establishing our Diversity Management Strategy demonstrates our commitment to ensuring an appreciative company culture based on mutual respect. We are also implementing diversity-sensitive processes throughout our whole organization."

Your tasks

Perform and analyze imaging data from human and murine lung tissues
Integrate single-cell transcriptomics with imaging and metabolomics data
Explore cell-cell interactions in ex vivo human lung models, including precision cut lung slices and immunocompetent organoids
Present work in national and international scientific meetings
Write reports and carry out other duties as assigned

Your profile

Master's degree in immunology or similar
Proficiency in written and spoken English
Experience in human cell culture, immunofluorescent microscopy/immunohistochemistry, multi-color flow cytometry and molecular biology methods
Enthusiasm to work in an interdisciplinary group consisting of basic scientists, clinicians and bioinformaticians
Strong organizational and time management skills; capable of handling multiple tasks
Proactive and forward-thinking approach
Dedication and full commitment to the research objectives
Open to continuous learning and ability to work independently

Will be considered a plus:

Familiarity with genomics technologies
Previous experience in programming (R/Python)

Benefits

Scientific Training

Helmholtz Munich Graduate School

Career counseling

Career Center for PhD candidates

Recreation

30 days annual leave, flexi days, plus public holidays

Health Promotion

Sports, company doctor, mental health initiatives

International Staff Service

Support with the relocation and integration process in Germany

Scientific Training: Helmholtz Munich Graduate School
Career counseling: Career Center for PhD candidates
Recreation: 30 days annual leave, flexi days, plus public holidays
Health Promotion: Sports, company doctor, mental health initiatives
International Staff Service: Support with the relocation and integration process in Germany

This position provides the opportunity for you to build specialist knowledge whilst developing key professional experience, both of which will help you to make strides in your scientific career.

Remuneration and social security benefits are based on the German Collective Wage Agreement for Public-Sector Employees at Federal Level (EG 13 50% TV EntgO Bund). In addition, there is also the possibility of receiving an allowance if the applicable conditions are met. The position has an (initial) fixed term of three years but may be extended under certain circumstances.

We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference. If you have obtained a university degree abroad, we will require further documents from you regarding the comparability of your degree. Please request the Statement of Comparability for Foreign Higher Education Qualifications as early as possible.

Interested in applying?

If you have any questions, feel free to contact Theodoros Kapellos, th*******.********os@he*******-******ch.de, who will be happy to help.

Your application should include

CV
Cover letter
Degrees/Diplomas/Certificates
Contact details for at least two referees

PhD-Kandidat*in (f/m/x) - Immune-non-immune Zell-Zell-Interaktionen bei chronisch obstruktiver Lungenerkrankung